ISO 13485 quality management system (TÜV SÜD)

Preclinical evidence

Evidence

Azyro's mechanism is supported by preclinical evidence, including SEM-confirmed cell wall disruption in MRSA, and has been reviewed by independent wound-care and antimicrobial-resistance researchers.

From intact cells to visible disruption

Azyro's non-invasive, low-intensity magnetic field is designed to break down bacterial cell walls.

  1. Beforeuntreated S. aureus cell
  2. Azyro magnetic field
  3. Aftertreated S. aureus cell
Transmission electron microscopy of an untreated methicillin-resistant S. aureus (MRSA) cell. Before
Transmission electron microscopy of a methicillin-resistant S. aureus (MRSA) cell after application of the Azyro magnetic field, showing morphological disruption of the bacterial cell wall. After
Transmission electron microscopy (TEM) images of methicillin-resistant S. aureus (MRSA) showing morphological disruption of the bacterial cell wall after application of the Azyro magnetic field.

Reaches deep. The field passes through the dressing into wound pockets that topical antiseptics do not reach full bioavailability.

Breaks defences. In SEM imaging, exposure to the field disrupts the bacterial cell wall and the surrounding biofilm, the barrier that keeps antimicrobials from reaching the bacteria.

Boost efficacy. Antimicrobials can better penetrate and disrupt biofilms.

Read more: magnetic-field wound therapy

Bringing biofilm damage to light

Bacteria form protective biofilms that resist treatment and avoid the body's natural defenses. In preclinical in vitro tests, our magnetic field destabilizes the biofilm and allows established antimicrobials to act on bacteria that biofilm otherwise protects.

P. aeruginosa biofilm and antiseptics

untreated Fluorescence microscopy of an untreated P. aeruginosa biofilm.
Azyro MF Fluorescence microscopy of a P. aeruginosa biofilm after the Azyro MF treatment.
PHMB Fluorescence microscopy of a P. aeruginosa biofilm after PHMB.
Azyro MF + PHMB Fluorescence microscopy of a P. aeruginosa biofilm after the Azyro MF treatment combined with PHMB.
Eradication of P. aeruginosa biofilm after the Azyro MF treatment and synergy with Polyhexamethylene biguanide (PHMB) using fluorescence microscopy. Bacteria are stained in green, while red dye penetrates damaged membranes.

Reviewed by researchers in wound care and antimicrobial resistance

Statements from independent researchers who have reviewed Azyro's preclinical results.

“Azyro’s research results to combat AMR bacteria are amazing. They exceed anything experts thought possible just a few years ago. Azyro has not only achieved a mindblowing scientific breakthrough. They have also managed to translate their research findings into a viable, highly effective treatment system.”

Prof. Axel Kramer Prof. Axel Kramer University Medicine Greifswald

“Modern technologies with antibacterial effects play a pivotal role in preventing infections. Their correct application and development can make the difference between successful wound healing and complications. Azyro has the potential to make that difference.”

Prof. Adam Feliks Junka Prof. Adam Feliks Junka Wroclaw Medical University
EP2025/068630 and EP4400155ISO 13485 quality management system (TÜV SÜD)

Bring Azyro to your wound-care unit

Azyro develops magnetic-field technology for chronic infected wounds. Our goal is to reduce the infection-driven complications that lead to amputation. We are looking for clinical, distribution and investment partners to get there.